Chemical Biology of Sox9
Indolactam V
indolactam V
Indolactam V was found by (Chen et al 2009) to increase the levels of Sox9 expression in mouse AV3-Pdx1 expressing cells that were induced to differentiate by incubation of Nodal for 5 days. Indolactam's concentration was at 300 nM.
This small molecule most likely does not directly interact with Sox9, but binds and activates PKC (Irie et al 2004), which then sends signals to cause Sox9's upregulation downstream of PKC.
This small molecule most likely does not directly interact with Sox9, but binds and activates PKC (Irie et al 2004), which then sends signals to cause Sox9's upregulation downstream of PKC.
References
- Irie, K., Nakagawa, Y., Ohigashi, H. (2004) Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes. Curr Pharm Des 10: 1371-85.
- Chen, S., Borowiak, M., Fox, J.L., Maehr, R., Osafune, K., Davidow, L., Lam, K., Peng, L.F., Schreiber, S.L., Rubin, L.L., Melton, D. (2009) A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol 5: 258-65.
